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Pharmacology: Omeprazole is an antisecretory agent, benzimidazole derivative, which suppresses gastric acid secretion by inhibition of the H+/K+ ATPase enzyme activity (proton pump) at the secretory surface of the gastric parietal cell at pH <4. Omeprazole which binds to proton (H+) will be changed rapidly to sulfenamide, an active proton-pump inhibitor.
Omeprazole is absorbed rapidly. 95% of Omeprazole is bound to plasma protein. Omeprazole is completely metabolized, especially in the liver. Approximately 80% of its metabolite is excreted through the urine and the remainder is excreted into the faeces.
